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Anthony Gonzalez Miguel Rivera (voice)

Gael García Bernal Héctor (voice)

Benjamin Bratt Ernesto de la Cruz (voice)

Alanna Ubach Mamá Imelda (voice)

Renée Victor Abuelita (voice)

Jaime Camil Papá (voice)

Alfonso Arau Papá Julio (voice)

Herbert Siguenza Tío Oscar / Tío Felipe (voice)

Gabriel Iglesias Clerk (voice)

Lombardo Boyar Plaza Mariachi / Gustavo (voice)

Ana Ofelia Murguía Mamá Coco (voice)

Natalia Cordova-Buckley Frida Kahlo (voice)

Sofía Espinosa Mamá (voice)

Selene Luna Tía Rosita (voice)

Edward James Olmos Chicharrón (voice)

Carla Medina Departures Agent / Additional Voices (voice)