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Casey Kasem Shaggy Rogers (voice)

Frank Welker Scooby-Doo / Fred Jones / Wiki-Tiki / Interviewer (voice)

Mindy Cohn Velma Dinkley (voice)

Grey DeLisle Daphne Blake / Auntie Mahina / Local Woman #2 (voice)

Ray Bumatai Little Jim (voice)

Tia Carrere Snookie / Local Woman #1 (voice)

Teri Garr Mayor Molly Quinn (voice)

Mario López Manu Tuiama / Mainland Surfer (voice)

Adam West Jared Moon (voice)

Don Ho Special Musical Guest (voice)

Dick Dale Special Musical Guest #2 (voice)

Don Ho Special Musical Guest #1 (voice)

Dee Bradley Baker Tiny Tiki / Surfer on Bike / California Surfer Dude / Local Guy #1 / Wild Pig / Gecko / Flame Thrower (voice)

Tom Kenny Ruben Laluna / California Surfer / Tiny Tiki (voice)